Scientists uncover genetic link to ME/chronic fatigue syndrome

Scientists uncover genetic link to ME/chronic fatigue syndrome

Tuesday, August 19, 2025 / No Comments

 

Scientists have uncovered the first solid evidence that genetics play a role in the development of myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME/CFS) , a condition that has long been neglected, misunderstood, and often dismissed by sections of the medical community.

The world’s largest investigation into the genetics of ME/CFS, led by the DecodeME project at the University of Edinburgh, analysed DNA samples from more than 27,000 patients and compared them with over 250,000 healthy participants. Researchers found eight regions of the genome with clear differences in those diagnosed with ME/CFS.

The findings suggest that common genetic variations many linked to the immune system and nervous system could tip the balance toward the illness, which is estimated to affect 67 million people globally.

Prof Chris Ponting, a lead investigator on the study, called the results “a wake-up call”, adding:“These findings provide the first robust evidence for genetic contributions to ME. They show that people’s biology really does matter when it comes to this condition.”

Patient groups hailed the research as a milestone moment. Sonya Chowdhury, chief executive of Action for ME, said the discovery brought “validity and credibility” to millions of people who have long been disbelieved or told their illness was not real.

ME/CFS symptoms include extreme fatigue, brain fog, chronic pain, sleep disturbances, and post-exertional malaise, where even light activity can cause prolonged relapses. There is currently no diagnostic test and no cure.

The DecodeME team hopes the findings will pave the way for future treatments and better recognition of a disease that costs the UK economy more than £3bn each year.

While the genetic evidence sheds light on possible mechanisms, questions remain. Researchers are still investigating why women are disproportionately affected, and how the condition relates  if at all to long Covid.

For patients, the discovery represents progress after decades of frustration. “This doesn’t give us a cure,” said Andy Devereux-Cooke, a patient researcher on the project, “but it gives us hope  and that is huge.”

Europe’s Glaciers Vanishing at Record Pace, Scientists Warn

Europe’s Glaciers Vanishing at Record Pace, Scientists Warn

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Morteratsch, Switzerland High in the Alps, the path to the Morteratsch Glacier grows longer every year as ice continues to retreat at alarming speed. What was once a solid wall of frozen mass is now a valley of rock, meltwater, and unstable terrain.

Leo Hösli, a researcher studying the glacier, has watched the transformation up close. Earlier this summer, he tried to measure the ice caves with markers he had placed months earlier. By August, most of those stakes had disappeared melted away or buried under collapsing ice.“It’s just too warm for the glacier to exist at this state right now,” Hösli said.

Europe’s glaciers are shrinking faster than anywhere else on Earth. A landmark study in Nature found glaciers in the Alps and Pyrenees have lost about 40% of their mass since 2000. The years 2022 and 2023 set new records for ice loss, coinciding with unprecedented global heat.

The Morteratsch Glacier has receded more than two miles in 165 years, becoming one of the world’s most closely monitored indicators of climate change. Visitors hiking the route can see signposts marking where the ice once stood  reminders of how quickly the landscape is transforming.

Glaciers aren’t just natural wonders. They sustain agriculture, tourism, and provide critical drinking water across Europe. Their disappearance is destabilizing the mountains, triggering landslides that endanger villages. In May, the Swiss town of Blatten was destroyed by a glacial slide.

In Austria, Andrea Fischer of the Academy of Sciences warns that one-third of the country’s glaciers will vanish within five years. The Stubai Glacier, one of Austria’s most popular ski destinations, is projected to disappear entirely by 2033.“The end of the Alpine glaciers is really coming very, very close,” Fischer said. “It’s not a computer model. It’s happening in front of our eyes.”

Global warming has already raised Austria’s temperatures by 3.1°C since 1900, more than twice the world average. And despite experimental efforts to slow the melt  like snowmaking or covering ice with reflective sheets  scientists now say only major cuts to greenhouse gas emissions can preserve what remains.“There is no possibility to save glaciers without saving the climate,” Fischer said.

Still, researchers stress it’s not too late. Vast amounts of ice remain, and action now could slow further loss.“It’s not a completely lost cause,” Hösli said, glancing up at Morteratsch’s shrinking mass. “There’s still something we can do. It’s too early to give up.”

Frozen Earth: How Ancient Volcanoes Triggered a Global Ice Age

Frozen Earth: How Ancient Volcanoes Triggered a Global Ice Age

Thursday, July 24, 2025 / No Comments

A dramatic global freeze that turned Earth into a giant snowball around 700 million years ago may have been triggered by massive volcanic eruptions and a lack of plant life, new research suggests.

Scientists studying the so-called “Snowball Earth” period say the event may have been set off by the Franklin eruptions, a series of massive volcanic events that occurred roughly 720 million years ago across what is now northern Canada, Alaska, and Greenland.

While other volcanic episodes of similar scale have occurred in Earth’s history, this one was different: it coincided with an already cold global climate and took place before land plants had evolved. Without plant cover to slow erosion, newly formed volcanic rock was rapidly weathered, pulling large amounts of carbon dioxide out of the atmosphere.

“Chemical weathering acts like a thermostat for Earth’s climate,” researchers explained. “But if that thermostat removes too much CO₂ too quickly, the planet cools rapidly.”

The sharp drop in atmospheric CO₂, a key greenhouse gas, is believed to have pushed Earth over a tipping point, resulting in a planet-wide deep freeze even in equatorial regions.

The study, published in the Journal of Geophysical Research: Planets, used climate models to test the effects of large-scale erosion caused by the eruptions. It found that similar volcanic activity during warmer periods in Earth’s history did not cause global glaciation, in part because vegetation helped stabilize the climate.

Researchers say the findings highlight how closely Earth’s climate is tied to geological and biological processes and how seemingly small changes in conditions can lead to dramatic consequences.

Ancient Irrigation Systems Offer Clues for Modern Water Scarcity in Peru

Ancient Irrigation Systems Offer Clues for Modern Water Scarcity in Peru

Wednesday, April 9, 2025 / No Comments

 

In northern Peru, one of the driest deserts in the world, the landscape is unexpectedly lush, thanks to a centuries-old network of irrigation canals. These canals, dating back over 1,400 years, have been vital in turning the region into the nation’s agro-industrial hub, supporting crops like sugarcane, asparagus, and blueberries. However, the delicate balance these systems rely on is under threat as climate change and modern agricultural practices exacerbate water shortages and intensify floods.

The government’s recent multibillion-dollar investments aim to bolster the region’s water supply by drawing from glaciers in the Andes, located more than 100 miles away. But as global temperatures rise, these glaciers are rapidly shrinking, and the water they provide is becoming increasingly unreliable. Adding to the challenge, floods, often triggered by El Niño events, are damaging vital infrastructure.

Looking back at Peru’s pre-Hispanic canal systems offers a potential blueprint for tackling these modern challenges. Unlike the rigid, permanent designs of today’s infrastructure, the ancient systems were flexible and multifunctional, designed to adapt to both dry spells and flash floods. Aqueducts acted as sediment traps, and check-dams helped manage floodwaters, all part of an intricate network that made the most of the desert’s extreme conditions.

The Spanish colonialists who arrived in the 16th century tried to replicate these systems but failed to understand the cultural knowledge that underpinned them. The results were disastrous, with records from the time describing the collapse of irrigation networks and the desert reclaiming the once-fertile valleys.

Today’s challenge is not just about building new infrastructure but understanding how these ancient systems worked in harmony with the environment. The Peruvian government’s current project to bring water from melting glaciers may offer temporary relief, but as these glaciers continue to disappear, long-term solutions must consider the lessons of the past, particularly the cultural and adaptive practices that helped sustain ancient societies for centuries.

Preserving these ancient practices and understanding the cultural logic behind them could be key to developing sustainable solutions for modern-day water scarcity and climate adaptation.

Scientists Turn to Queen Bees in Search of Secrets to Longevity

Scientists Turn to Queen Bees in Search of Secrets to Longevity

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For centuries, the mysterious life of queen bees has intrigued scientists. Unlike their worker counterparts, queen bees enjoy extended lives, thriving for years while workers live only a few months, despite having nearly identical genetic material. This unusual longevity has led researchers to investigate whether the key to longer human lives could be found in the biology of these remarkable insects.

This investigation is part of an ambitious new initiative funded by the UK’s Advanced Research + Invention Agency (Aria), a government body backed by £800 million. Aria is focused on supporting high-risk, high-reward projects that may reshape our understanding of aging and fertility efforts that might fail but could also revolutionize human health if successful.

Yannick Wurm, professor of evolutionary genomics and one of Aria’s program directors, sees a potential breakthrough in understanding how nature has solved problems like aging and fertility in animals. "If we can reverse engineer how these creatures achieve their longevity, it could transform human health," he said. The project could have far-reaching applications, from extending human lifespans to improving organ transport and combating diseases.

Aria’s directors are pursuing diverse, nature-inspired solutions, including replacing plastics with sustainable materials, harnessing atmospheric energy for flight, and exploring novel ways to manipulate the immune system to fight diseases. The project on queen bees builds on previous discoveries that have already extended the life of worker bees by transplanting gut microbes from queens.

In their natural environment, queen bees live long lives due to a combination of factors: they mate mid-flight, store sperm from multiple males, and are nurtured with royal jelly, a nutrient-rich secretion. The secrets contained within this royal jelly and the microbes it supports are of particular interest to scientists aiming to unlock the potential for extending human health and fertility.

This project is one of several bold ideas being explored by Aria, a research body modeled after the influential U.S. Defense Advanced Research Projects Agency (DARPA), which is known for its groundbreaking technological innovations.

Despite the potential, Aria acknowledges the high level of uncertainty inherent in such speculative research. “We often describe our programmes as sending up a flare,” says Pippy James, Aria’s chief product officer. “It’s about showing that something is possible, even if it takes time to bear fruit.”

Discovery of Stone Tools in China Suggests Possible Neanderthal Presence

Discovery of Stone Tools in China Suggests Possible Neanderthal Presence

Wednesday, April 2, 2025 / No Comments

 

Archaeologists in China have uncovered a collection of ancient stone tools that may reshape our understanding of early human history in East Asia. The tools, found at the Longtan site in Yunnan province, bear a striking resemblance to those crafted by Neanderthals in Europe, raising questions about whether the species may have once inhabited the region.

The discovery, detailed in a study published in Proceedings of the National Academy of Sciences, marks the first time Quina-style stone tools previously associated with Neanderthals have been found in East Asia. Researchers say the find suggests two possible scenarios: Neanderthals may have migrated much farther east than previously thought, or another ancient human species, such as Denisovans, developed similar tool-making techniques independently.

The tools, which include scrapers and points that may have been used for hunting, were dated to between 60,000 and 50,000 years ago. Analysis of ancient pollen from the site indicates that the environment in southwestern China at the time was similar to that of Europe, where Neanderthals used Quina tools to survive harsh conditions.

However, no Neanderthal fossils have been found in China, and experts caution against drawing definitive conclusions. "Stone tools are not ID cards," said John Shea, an anthropologist at Stony Brook University. More evidence, such as DNA or fossils, will be needed to confirm whether Neanderthals once lived in the region.

The findings contribute to growing research highlighting East Asia as a key region in the study of human origins, challenging previous assumptions that early human innovation was concentrated in Europe and Africa.

New Blood Test for Alzheimer’s Could Help Diagnose and Track Disease Progression

New Blood Test for Alzheimer’s Could Help Diagnose and Track Disease Progression

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Scientists have developed a new blood test that can detect Alzheimer’s disease and assess how far it has progressed. Researchers say the test could help doctors determine the most suitable treatments for patients, particularly newer drugs like donanemab and lecanemab, which are most effective in the early stages of the disease.

The study, led by Prof. Oskar Hansson from Lund University and published in Nature Medicine, found that a specific tau protein fragment, called eMTBR-tau243, was present in the blood of people with Alzheimer’s. The researchers analyzed data from 902 participants and discovered that higher levels of this tau fragment were strongly linked to cognitive impairment and dementia in Alzheimer’s patients, but not in those with other neurological conditions.

Experts say the findings are promising, but the test is not yet ready for routine clinical use. Prof. Tara Spires-Jones from the University of Edinburgh noted that the method requires complex laboratory techniques and further validation.

In a related study, researchers from the US, Sweden, and Finland identified another potential marker for Alzheimer’s progression. They found that the ratio of two proteins in brain fluid YWHAG and NPTX2 was more closely linked to cognitive decline than the presence of amyloid beta plaques and tau tangles, the known hallmarks of Alzheimer’s.

Scientists believe these discoveries could lead to more precise diagnoses and better monitoring of the disease, ultimately improving treatment strategies for patients.