Women with Alzheimer’s Show Markedly Lower Omega Fatty Acid Levels, Study Finds
New research suggests that women with Alzheimer’s disease have significantly lower levels of omega fatty acids in their blood compared with healthy women, a pattern not observed in men.The study, conducted by King’s College London and published in Alzheimer’s & Dementia, analyzed blood samples from more than 800 participants, including 306 Alzheimer’s patients. Researchers found that women with the disease had up to 20% lower levels of unsaturated fats, including omega-3 fatty acids, and higher levels of saturated fats.
“This difference between men and women was the most surprising outcome,” said Dr Cristina Legido-Quigley, senior author of the study. “It hints at a potential causal link, but clinical trials are needed to confirm whether supplementing these fatty acids could help prevent or delay the disease in women.”
Alzheimer’s affects women at twice the rate of men, a disparity attributed to factors such as lifespan, hormones, immune response, and social conditions. The study’s findings may shed light on why the disease manifests differently in women.
Omega-3 fatty acids found in oily fish, chia seeds, flaxseed, and walnuts are known to support brain and heart health. While previous trials of omega-3 supplements in older adults have shown limited benefit for cognitive decline, researchers now hope targeted trials for women could offer new insights.
Dr Julia Dudley of Alzheimer’s Research UK, a co-funder of the study, emphasized the importance of understanding sex-specific disease mechanisms. “This research could inform tailored treatments and lifestyle advice, potentially improving prevention strategies for women,” she said.
In the meantime, experts recommend that women ensure adequate intake of omega fatty acids as part of a balanced diet.
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