News Ticker

Menu

Browsing "Older Posts"

Browsing Category "HEALTH"

Study Finds Extra Education Does Not Prevent Brain Aging

Tuesday, November 5, 2024 / No Comments

 

Researchers were surprised to find that an additional 12 months of schooling did not affect brain structure or provide protective benefits.

Scientists from Radboud University Medical Centre in The Netherlands leveraged a “natural experiment” involving 30,000 British participants to precisely assess the long-term impact of an extra year of education on the brain.

Previous studies have highlighted many positive outcomes of education.

Generally, individuals who spend more time in school tend to be healthier, more intelligent, hold better jobs, and earn higher incomes compared to those with fewer years of education.

However, it remains uncertain whether extended education leads to changes in brain structure over the long term and guards against brain aging.

Many other factors impact brain structure – including childhood environment, genetic traits, and exposure to pollution – making it challenging to isolate the effects of education.

Prof. Rogier Kievit and Dr. Nicholas Judd of Radboud University recognized a “unique” opportunity to assess the effects of an additional year of schooling.

In 1972, a change in UK law increased the minimum school-leaving age from 15 to 16, while other conditions remained unchanged.

The researchers described this as an intriguing ‘natural experiment,’ an event outside their control that created exposed and unexposed groups.

For their study, published in eLife, data from 30,000 individuals who attended school during that period, including MRI scans taken 46 years later, were used, marking it as the largest brain imaging dataset globally.

The team analyzed the MRI scans for structural differences in various brain regions but found no significant differences between those with an extra year of schooling and those without.

Dr. Judd commented, “This surprised us.

“We know education has positive effects, so we anticipated that it might protect against brain aging.

“Age-related changes are evident in our MRI data, showing declines in total brain volume, surface area, cortical thickness, and poorer water diffusion. However, the extra year of education doesn’t seem to impact these areas.”

The researchers noted that while changes in the brain may have been evident right after the additional year of education, this was not captured in the study.

Kievit added: “It’s possible that education temporarily increases brain size, but it returns to its baseline later. After all, the brain must fit within the skull.

“It might be similar to physical training: intense exercise at 16 could enhance muscle size, but the effect may not last 50 years later.”

The team suggested that the extra education might induce microscopic brain changes that MRIs cannot detect.

Previous research and smaller studies have indicated that more education correlates with brain benefits.

For instance, individuals with more education tend to have better cognitive functions, superior health, and higher job prospects.

Kievit pointed out, however, that these associations are not evident in brain structure as viewed through MRI.

He concluded, “Our findings emphasize caution when interpreting causation from mere correlations.

“While we observe correlations between education and the brain, we do not see evidence of changes in brain structure.”

Wearable Devices for Neurons: Probing Brain Function and Restoration

Saturday, November 2, 2024 / No Comments


 MIT Scientists have developed innovative "wearable" devices that can wrap around neurons, offering new possibilities for probing and interacting with subcellular regions of the brain. These microscopic devices are designed to conform tightly to individual neurons, allowing for high-precision measurements and interactions at the cellular level. The concept is similar to wearable technology for humans but scaled down to interact directly with cells.

The primary applications of these neuronal "wearables" include detailed mapping of electrical and chemical signals in subcellular areas, which could provide deeper insights into how the brain functions at the most intricate levels. By accessing and monitoring these tiny regions, researchers can better understand processes like signal transmission and synaptic activity. This could lead to breakthroughs in understanding neurological diseases and disorders.

Moreover, there is potential for these devices to be used in therapeutic applications. For example, they could be engineered to deliver electrical stimulation or drugs directly to specific parts of the brain, possibly aiding in the restoration of lost brain functions or modifying neuronal activity to address disorders such as epilepsy or Parkinson's disease.


This new approach marks a significant step in neurotechnology, merging micro-engineering and neuroscience to create tools that are more integrated with biological structures than ever before.

New study shows that blood-based tests for colon cancer are not as effective as colonoscopies

/ No Comments

 


A study led by Stanford Medicine has found that blood tests can be a useful screening option for colorectal cancer for patients who might otherwise not undergo screening. However, these blood tests are not as effective as traditional screening methods like colonoscopies or stool-based tests.

Colonoscopy remains the gold standard for detecting colorectal cancer because it allows direct visualization of the colon and removal of precancerous polyps. Stool tests, such as fecal immunochemical tests (FIT) or stool DNA tests, are also proven to be effective non-invasive screening methods. Blood tests, while more convenient, tend to have lower sensitivity and may miss more cases compared to these established methods.

The researchers suggest that blood tests could play an important role in increasing screening rates among individuals who avoid more invasive or inconvenient methods. This could help identify cases of colorectal cancer earlier, when treatment is more effective. The findings highlight the need for continued patient education about the most effective screening options and the potential role of blood tests as a secondary alternative for those unwilling or unable to undergo standard screenings.

Blood Analysis Finds Heart Damage Linked to Inflammation in Long COVID

Thursday, October 31, 2024 / No Comments
Research led by the University of Queensland has identified inflammatory markers in the blood of long COVID patients, potentially explaining why many continue to suffer from cardiovascular issues


Associate Professor Kirsty Short explained that her team aimed to uncover the reasons behind persistent chest pain and heart palpitations frequently reported by long COVID patients.

"We found elevated cytokine levels—proteins that regulate inflammation—in blood samples from individuals about 18 months after SARS-CoV-2 infection," Dr. Short said.

"Lab tests demonstrated that even trace amounts of these cytokines had a direct impact on cardiomyocytes, the heart cells responsible for its pumping function."

According to Dr. Short, the role of chronic inflammation in prolonged cardiovascular symptoms was previously unclear, particularly in people with symptoms persisting beyond a year post-infection.

Published in Nature Microbiology, the study analyzed blood samples from 50 participants in Australia, including those with long COVID lasting over a year, people who had recovered from COVID, and individuals never infected with the virus.

The research team utilized "immuno-storm chip" nanotechnology, created at UQ's Australian Institute for Bioengineering and Nanotechnology (AIBN), to detect trace cytokine levels and cardiac tissue damage markers at single-molecule resolution in long COVID patients.

"It's still early days, and these findings need validation in additional patient groups, particularly those infected with newer SARS-CoV-2 variants," Dr. Short said.

"We’re also interested in exploring whether our results might apply to other long COVID symptoms, such as neurological or respiratory issues, since this study specifically focused on patients with chest pain and/or heart palpitations."

"Despite these limitations, this work sheds new light on the complexity of long COVID and could pave the way for improved diagnosis, treatment, and understanding of the condition."

This research was led by UQ Ph.D. candidates Jane Sinclair from the School of Chemistry and Molecular Biosciences (SCMB), Courtney Vedelago from AIBN, and Dr. Feargal J. Ryan from the South Australian Health and Medical Research Institute.

The study was a collaborative effort involving UQ's SCMB, School of Mathematics and Physics, AIBN, Institute for Molecular Bioscience, Faculty of Medicine, along with the South Australian Health and Medical Research Institute, Flinders University, the University of Adelaide, the Australian National University, Mater Health Queensland, Mater Research Institute—UQ, and QIMR Berghofer Medical Research Institute.

Research samples were provided by the COVID OZGenetics study, Central Adelaide Health Network, and the David Serisier Research Biobank at Mater Research.














A New Implant Shows Promise in Reversing Drug Overdoses

Wednesday, October 30, 2024 / No Comments

 

This implantable device, though not yet tested in humans, shows promise in reducing opioid deaths, particularly among high-risk individuals. Designed to be placed under the skin similarly to a pacemaker, it has the potential to automatically detect an overdose and deliver life-saving naloxone.

 Joanna Ciatti/Northwestern University


Naloxone has been a life-saving treatment for reversing opioid overdoses, but its effectiveness depends on someone being present to administer it promptly—a challenge when many overdoses occur when individuals are alone. To address this issue, researchers have developed an implantable device called the Naloximeter. Powered by a battery and inserted under the skin, the device is capable of detecting the onset of an overdose, then automatically releasing naloxone into the bloodstream while alerting first responders. This innovative approach, reported on October 23 in Science Advances, has so far been tested only in animal models.

Researchers hope the Naloximeter implant could benefit high-risk individuals, particularly those who are newly sober after treatment or incarceration. People in early recovery face a 10 to 16 times higher risk of fatal overdose, as their opioid tolerance has diminished.
In 2023, the U.S. saw over 80,000 opioid overdose deaths. Robert Gereau, a neuroscientist at Washington University in St. Louis, emphasized the urgent need for new harm reduction methods to combat the worsening fentanyl crisis.

Traditional methods, like safe injection sites and hotlines, offer support when bystanders are present, while newer apps can alert responders. The Naloximeter, however, goes further: it actively delivers naloxone during an overdose, filling a critical intervention gap.
The Naloximeter’s sensor monitors oxygen levels, detecting the sudden drops characteristic of overdose. In future human applications, an alert would appear on the person’s phone, allowing them to dismiss it if false; otherwise, naloxone would be administered.

In animal trials, Gereau’s team tested various delivery methods. In pigs, they found that an intravenous catheter within the implant worked best, delivering 0.7 milliliters of naloxone in under a minute—enough for rapid brain action, notes materials scientist Joanna Ciatti of Northwestern University.

While clinical trials in humans are still distant, the technology is promising. Addiction researcher Monty Ghosh at the University of Alberta points out that its success will depend on the device's invasiveness, cost, and whether those at risk are open to such an intervention.

Scientists Discover Six New Genes Associated with Increased Cancer Risk

Tuesday, October 29, 2024 / No Comments

Scientists at decode genetics/Amgen, along with collaborators, have identified six novel genes with rare germline variants associated with cancer risk. Published in Nature Genetics under the title "Gene-based burden tests of rare germline variants identify six cancer susceptibility genes," the study provides new insights into genetic predispositions to cancer.

Certain cancers are linked to rare genetic variants inherited from birth, significantly increasing cancer risk. Discoveries of variants like those in the BRCA1 and BRCA2 genes have led to advancements in early detection and targeted therapies, which have improved outcomes for individuals with these mutations.

In this study, researchers analyzed genetic data from 130,991 cancer patients and 733,486 controls, all of European descent, across 22 cancer types. The gene-based burden analysis revealed four novel genes linked to higher cancer risks: BIK for prostate cancer, ATG12 for colorectal cancer, TG for thyroid cancer, and CMTR2 for both lung cancer and cutaneous melanoma. Variants in these genes increased cancer risk by 90% to 295%, although the study design limits accurate lifetime risk estimates.

Remarkably, the researchers also identified genes with rare variants associated with reduced cancer risk. Specifically, loss of AURKB was found to confer protection against various cancers, while loss of PPP1R15A was linked to a 53% reduction in breast cancer risk. This suggests PPP1R15A inhibition could serve as a potential therapeutic approach for breast cancer.

These findings shed light on the biological mechanisms of cancer susceptibility, paving the way for improved screening and treatment strategies.


Off-label glucose-lowering drugs Poses Risks for Type 1 Diabetes Patients

Monday, October 28, 2024 / No Comments

 

A collaborative study led by Emory University's Rollins School of Public Health highlights the risks associated with prescribing off-label glucose-lowering medications to individuals with type 1 diabetes (T1D). Researchers express concern over the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 (SGLT2) inhibitors, which have demonstrated cardiovascular and renal benefits in type 2 diabetes but pose unique dangers for T1D patients.

SGLT2 inhibitors, in particular, are linked to a significant risk of euglycemic diabetic ketoacidosis, a potentially life-threatening condition characterized by dangerously high acid levels in the blood, common in T1D individuals. Consequently, these medications have been removed from use in T1D patients in Europe, and the U.S. Food and Drug Administration (FDA) has not approved them for this population.

GLP-1RAs are known for promoting weight loss, which can complicate insulin needs and lead to risks such as ketoacidosis and hypoglycemia in T1D patients. The research letter published in JAMA emphasizes the urgent need for further studies to assess the safety and efficacy of these medications for T1D.

Analyzing data from the Epic Cosmos database, the study identified 943,456 T1D patients from 2010 to 2023. It found that those prescribed SGLT2 inhibitors had higher rates of pre-existing cardiovascular issues and chronic kidney disease, indicating these drugs are being used off-label to manage complications associated with T1D.

Meanwhile, the usage of GLP-1RAs increased significantly among T1D patients, particularly for managing obesity, which is a vital aspect of diabetes care. The study noted that the percentage of T1D patients prescribed GLP-1RAs rose from 0.3% in 2010 to 6.6% by 2023.

Despite the growing trend in off-label prescriptions, concerns remain regarding the safety of these treatments in T1D. The researchers call for prospective studies to evaluate the efficacy and safety of GLP-1RAs and SGLT2 inhibitors for T1D patients before widespread adoption of these medications. Until more evidence is available, caution is advised in their prescription for individuals with type 1 diabetes.

CO2 concentration exceeds 400 ppm, a record

Monday, May 11, 2015 / No Comments

According to NOAA, the rate of concentration of carbon dioxide in the atmosphere, in March exceeded 400 parts per million, the highest ever measured content. Yet, emissions have stagnated in 2014.

March 2014: 398.10 ppm (parts per million by volume). March 2015: 400.83 ppm. NOAA, the National Oceanic and Atmospheric Agency US, has announced a record. Every week, this rate is measured on Mauna Loa volcano in Hawaii, NOAA and establishes the monthly global content based on 40 sites worldwide. This is the first time the content of the atmosphere of carbon dioxide (carbon dioxide, or CO2) exceeds 400 ppm.

Yet, according to the IEA (International Energy Agency), as reported by the press NOAA, global emissions of carbon dioxide by fossil fuel combustion stagnated between 2013 and 2014. The atmospheric content has nevertheless increased by 2 25 ppm per year between 2012 and 2014, "the highest increase recorded over three years."

Since the beginning of the industrial age, the concentration of CO2 has increased by 120 ppm, "half of the increase occurring since the 1980s." According to James Butler, NOAA, "the elimination of approximately 80% of emissions from fossil fuels stop the progression of the atmospheric content of carbon dioxide, but it will not decrease and no further reduction would only do so slowly ".

Diesel particles attack the liver function

Tuesday, April 21, 2015 / No Comments

Allowing the body to eliminate certain toxic elements, the liver plays a vital role in the human body. A study has shown that diesel particulate disrupt its detoxifying liver function by blocking certain carriers. The health implications are not yet well known. This could include enhancing the carcinogenic effects of diesel related to oxidative stress.

Diesel station! The fine particles are not only toxic to the lungs, but they are also able to cross the lung barrier and attack other organs. He had indeed been shown that these particles alter the function of certain liver enzymes. A new study shows this time they can also impair the liver's detoxification function, that is to say its ability to sort and eliminate toxic waste to the body.

The origin of this discovery researchers (Inserm Unit 1085, research institute Health, environment and labor, Rennes) worked in vitro on liver cells (hepatocytes) in culture. They have them exposed to extract particles from combustion of a diesel engine (DEP Diesel exhaust particles) at doses equivalent to those inhaled by an individual living in a polluted environment. The researchers then measured the level of expression and activity of several carriers at the cell surface. Their findings appear in the journal Plos One.

These hepatic transporters ensure the passage of molecules circulating in the blood to the inside of the liver. Bile then led to the elimination of these substances. The whole system allows the body to get rid of natural waste products from the cells, medicines or drugs. However, the authors found that DEP reduces the expression of genes encoding these transporters and block the activity of several of them. The phenomenon is observed when the cells are exposed to low levels of particles.

The MRP2 and OATP transporters inhibited

In particular, researchers found a strong inhibition of MRP2 and OATP transporters involved in the hepatic elimination of many toxic drugs, but also in that of sex steroid hormones and thyroid hormones. Blocking the activity of MRP type carriers could also disrupt control circuits of glutathione, an important endogenous antioxidant molecule.

At this point, even if it comes to work in vitro, the spectrum of clinical consequences envisaged by the authors is wide: endocrine disruption, disturbance elimination of drugs and endogenous metabolites or excessive oxidative stress to poor elimination of free radicals, which can contribute to the development of chronic diseases. "This would include the effect of strengthening the carcinogenic effects of diesel favored by oxidative stress," says Olivier Fardel, co-author of this work to the research institute on health, the environment and labor.


Assumptions that drive to continue this work: for example, the authors wish to look towards the carriers present in the pulmonary cells (some of which are similar to those found on hepatocytes), focusing in particular on carriers associated with carcinogenesis. They count as precisely identify chemical molecules involved in the inhibition of transporters in the cocktail particles used in the context of their work. Finally, they want to extend their studies to potential interactions of membrane transporters with other chemical pollutants.

Eating too much fat may increase the risk of psychiatric disorders

Sunday, April 5, 2015 / No Comments

Diets high in fat may increase the risk of psychiatric disorders. Indeed, they change the composition of the intestinal flora, which also plays a role in brain health.

The intestinal flora (or gut microbiota) has about 100,000 billion bacteria, representing about 1,000 species. These microorganisms are involved in different biological functions: digestion, growth, inflammation, immunity, protection against pathogens. However, changes in the intestinal flora appear to be involved in certain diseases, including neuropsychiatric problems. For example, probiotics taken orally, expected to act on the composition of the intestinal flora, can reduce anxiety.

In addition, the prevalence of mental illness, such as depression and dementia increases with obesity. Studies have shown deficits in learning, memory, executive function in obese people compared to non-obese patients. Modern diets rich in fats and sugars, promote alterations in the gut microbiome.

Louisiana State University researchers have therefore asked whether the microbiome associated with obesity alter the behavior and cognition, even in the absence of obesity in the individual. For this, they used mice non-obese adults who followed a normal diet, but who they are transplanted mouse intestinal microbiota that were fed a high fat diet or a control diet. Their findings appear in Biological Psychiatry.

Anxiety, memory problems, repetitive behaviors

The animals that received microbiota of mice fed the fat have been changes in their behavior: increased anxiety, memory problems and repetitive behaviors. There was also a negative impact on their health: an increase in intestinal permeability and inflammation markers and brain inflammation signs that may have contributed to changes in behavior.

This article suggests that diets high in fats affect the health of the brain changes induced by food in the intestinal flora enough to impair brain function in the absence of obesity. The composition of the intestinal microbiota therefore influences the behavior of the individual.


Microbial metabolism of the gut produces histamine and other neuroactive mediators that could stimulate local nervous system. The gut-brain axis is therefore a potential target for new therapeutic interventions imagine against psychiatric diseases.


Men Never Remember and Women Never Forget

Sunday, March 22, 2015 / No Comments

The gradual deterioration of memory is a normal process associated with aging. But men seem affected earlier than women. Possible cause: that would be protective estrogen in women.

Progressive memory loss is a natural phenomenon during aging, which does not necessarily mean that the individual risk of developing dementia such as Alzheimer's. The anatomical level, this disease is characterized by accumulation of amyloid plaques in the brain. Some people carry the APOE ε4, have a higher risk of developing it.

Researchers at the Mayo Clinic studied the effect of age, gender, APOE ε4 gene and on memory, brain structure and amyloid β in adults. For this, they examined the brain structure of 1,246 people aged 30 to 95 years who had normal cognitive function. 1209 were between 50 to 95 years and 37 between 30 and 49 years to be exact. The researchers were interested in the volume of the hippocampus, a brain area important for the formation and storage of memory. Their findings appear in JAMA Neurology.

The hippocampal volume was reduced slowly and steadily from age 30 to the mid-sixties, but soon beyond. Overall, men had poorer memory than women, especially after 40 years, and the volume of the hippocampus was smaller in men than women, especially after 60 years. One hypothesis to explain this more rapid decline in men is hormone: estrogen might help women prevent damage to brain neurons to the middle of their lives.


Amyloid accumulations increase after 70 years

The researchers also used Pet scans to study amyloid accumulation in the brains of participants. They observed that there were no differences between men and women. Overall, amyloid levels were low in most people before the age of 70, but then increased.

Overall, the volume of the hippocampus and the memory did not differ, that individuals carry or not the predisposing allele in Alzheimer's disease. But after 70 years, those who carried the APOE ε4 allele had significantly more amyloid than others. The age at which 10% of the population was positive amyloid was 57 years for those who carried this allele and 64 for others.

Eventually, the worsening of memory and hippocampal volume occurs earlier than the accumulation of amyloid. This suggests that, in middle age, amyloid deposits are not responsible for the loss of memory or volume of the hippocampus. Alzheimer's disease and amyloid deposits are set up later, in a context of pre-existing cognitive and structural decline associated with aging

A cuff-thermometer solar

Saturday, February 28, 2015 / No Comments

A team of Tokyo University researchers recently presented a flexible cuff-thermometer. Self-powered by a solar panel, it sounds an alarm when the patient's temperature becomes too high. Made from organic components through an inkjet printer, cheap and disposable product is intended for use in a hospital setting.

The development of sensors to monitor vital functions is growing, whether smart textiles for sports or medical devices. Examples are numerous developments around the epidermal stamps. The stakes of these innovations are to design devices that are both minimally invasive, energy efficient and inexpensive to produce.

It is in this context that a team of Tokyo University researchers has developed a flexible cuff thermometer powered by a solar panel. Used on the skin or clothes, it beeps when the body temperature of the user exceeds the preset threshold can be between 36.5 and 38.5 ° C.

The cuff combines a flexible solar panel consisting of solar cells, amorphous silicon (a-Si), a piezoelectric speaker, a temperature sensor and a power supply circuit. The latter has been made from organic components deposited by an ink jet printer on a polymer film.

All elements of the cuff thermometer are flexible (flexible components), either photovoltaic cells (solar cells), the piezoelectric speaker (piezoelectric speaker), the fuel system and its management based on organic compounds (organic circuits) or the temperature sensor placed under the arm. © University of Tokyo

An inexpensive, disposable product for hospitals

The researchers say this is the first time such a device works with an organic origin supply circuit. This allows to increase by more than seven efficiency of the solar panel in indoor lighting conditions. This type of circuit is also configured to emit a sound: again, this would be a first. Flexible, self-powered, this armband could be manufactured at a low cost. What consider a single use, which perfectly appropriate for use respecting the rules of hygiene in hospitals.


Moreover, designers cuff specify that this system could be combined with the detection of other vital functions such as heart rate, blood pressure or sweating. The concept has been presented at the International Solid State Circuits Conference (IEEE) held this week in San Francisco (United States). There are currently no commercial project for this innovation.

A dangerous virus probably transmitted by ticks

Friday, February 27, 2015 / No Comments

Bourbon virus, new to the family Thogotovirus would be responsible for the death of a man in Kansas, United States. The patient fell ill in the spring of 2014 after being bitten by ticks. He died 11 days after the onset of disease.

Ticks are arachnids mites that can transmit diseases such as Lyme disease, caused by bacteria. But they can also transmit viruses, such as the Heartland virus, recently discovered, and which, since 2012, caused the illness of eight people in Missouri and Tennessee, United States. Other viruses that may be carried by ticks: the Thogotovirus, which comprise at least six viruses (Araguari, Aransas Bay Dhori Jos, Thogoto and Upolu). Among them, the Thogoto Dhori and viruses are known to cause infections and human diseases. Antibodies against the virus Thogoto have indeed been identified in parts of Europe, Asia and Africa.

In an article published in Emerging Infectious Diseases, CDC researchers describe the case of a man in his fifties died in 2014 in mysterious circumstances. This man, who was in good health, was bitten by several ticks while working outdoors on his property in the spring of 2014. engorged tick was found on his shoulder a few days before he fell ill. He began to have nausea, diarrhea, and became increasingly ill with the following symptoms: fever, anorexia, chills and headaches. The third day, he consulted his doctor and was prescribed doxycycline, a standard treatment against diseases related to ticks.

The next day, the patient's wife found him weakened, awake but with a decreased level of consciousness, hence its transfer to the local hospital. Despite treatment, the patient had more fever. The 9th day, it was still clear but the temperature exceeded 39 ° C and difficulty breathing required an oxygen supply. Its oxygen requirements increase, he was admitted in intensive care. His renal function deteriorated and he was intubated. He died 11 days after the onset of illness of cardiopulmonary arrest.

Bourbon virus, unknown Thogotovirus

The patient was tested for a large number of viruses but as none was found, his blood was sent to the CDC (Centers for Disease Control and Prevention) for further analysis. Genetic tests then showed that the man was infected with an unknown virus until then, scientists have dubbed "Bourbon virus", county name where the patient lived. This virus belongs to the family of Thogotovirus. Although the role of the virus in the death is unclear, the authors emphasize the patient's level of high viremia in samples taken two days before his death.

The Thogotovirus can cause meningitis or encephalitis, but they were not known to have an impact on blood cells. Or test the patient showed a decline in white blood cells and platelets. These symptoms resemble those of ehrlichiosis, a bacterial disease also transmitted by ticks.

Similarly, the Heartland virus can also cause a decrease of blood cells. It is possible that the Bourbon virus was present for years without it being noticed because it would have made sick person before. One hypothesis is that usually causes mild illness too that people go to their doctor. The death of this man would be a rare case where a common virus became deadly. But it is also possible that the virus has evolved and Bourbon became more dangerous.


To protect against ticks, the CDC recommends using repellent, wear long pants, long-sleeved t-shirts and avoid wooded areas.

Are E-Cigarettes Safe?

Wednesday, February 25, 2015 / No Comments

A scientific study  has shown that inhalation of high vapor electronic cigarette dose increases susceptibility to respiratory infections and releases free radicals. Not enough to get back to smoke tobacco that stopped but total safety remains unproven.

At Johns Hopkins University (Baltimore, USA), Professor Thomas Sussan and her team wanted to know if mice exposed to electronic cigarette fumes were or were not more susceptible to respiratory infections. To find out, they arranged a first group of rodents in an inhalation chamber. The animals breathed e-cigarette vapor for two weeks at levels, it seems equivalent to those of human exposure. In the second group, mice breathing fresh air.

To measure the susceptibility to infection, scientists have divided each group into three sub-groups: in the first, the mice received - Nasal - drops containing bacteria (Streptococcus pneumoniae) causing pneumonia and sinusitis. In the second, they were exposed to a type of influenza A. In the third, they received neither bacteria nor viruses.

The results are available in the journal Plos One. In the end, the researchers found that mice that had breathed electronic cigarette fumes were much more susceptible to infections. "The fumes inhibit the ability of mice to fight viral or bacterial infections that come to nest in their lungs," says Thomas Sussan. The authors show that these vapors emit free radicals, ie toxic substances that affect DNA. Their presence has surprised scientists because they are similar to those found in conventional cigarette fumes. "These free radicals, however, are 100 times lower in e-cigarettes, says Thomas Sussan. But they are still numerous enough to damage cells. »

Optimism it allows us to stay healthy?

Thursday, January 15, 2015 / No Comments

The most optimistic people were twice as likely to be in good cardiovascular health than pessimists. Action on the psychological well-being could therefore reduce cardiac risk.

See life in pink ... and if that was the secret to staying healthy? In an article published in the journal Health Behavior and Policy Review, the researchers wanted to know if there was an association between optimism and cardiovascular health.

For this, they used data from the Multi-Ethnic Study of Atherosclerosis which involved 6,000 people from six US regions. Cardiovascular 5134 aged 45 to 84 years were evaluated between 2002 and 2004 with seven measures: blood pressure, body mass index (BMI), fasting plasma glucose, cholesterol level in the blood, food intake, physical activity and smoking.


For each of these seven criteria, the researchers assigned a score of 0, 1 or 2, respectively representing a poor score, medium or "ideal". The sum provided a number between 0 and 14 and indicated cardiovascular health of the individual. A higher score foreshadowed better health. Participants also answered questions to determine their level of optimism and physical and mental state.

Cardiovascular risk factors reduced in optimistic

Results: cardiovascular health index of participants increased with optimism. Compared to pessimistic people, those who were the most optimistic were twice as likely to have a qualified heart health as "ideal". Optimists also had about 50% greater chance of getting an intermediate cardiovascular health score.

The link between cardiovascular health and optimism seemed very, explains lead author of the study, Rosalba Hernandez, a professor at the University of Illinois: "This association remained significant even after adjusting the results to the characteristics sociodemographic and mental health. "


Optimistic people had higher glucose levels in the blood and total cholesterol. They were also more physically active had higher BMI and were less often smokers.

Spiders do not transmit bacterial diseases

Wednesday, January 14, 2015 / No Comments

The bite of a spider is sometimes suspected of being the cause of bacterial infections. Yet a recent study shows that cases remain minimal. This misleading diagnosis unjustly incriminate the innocent little creatures.

Mosquitoes and ticks transmit diseases. But what about spiders? As bacteria are present on the hooks or mouthparts of these animals, we can imagine that the bite of a spider can transmit disease. Sometimes doctors and patients attribute to spiders cause of bacterial infections. The researchers wanted to know if proven cases of transmission of infections by spiders were many.

For this, a team of scientists led by an entomologist at the University of California, Richard Vetter, conducted a literature review on the topic. They extracted data from publications spider envenomation, that is to say, the disease caused by the entry of the venom into the body. The results of the study appear in the journal Toxicon.


According to this article, evidence of infection who had spiders to vectors are lean, explains Richard Vetter, the lead author, "In reviewing reports of thousands of bites of many species spiders in the world, we have found almost no mention of infection associated with an injury inflicted by an arachnid. "

Spiders are not vectors of bacterial infections

An exception seems to confirm this rule. Of all the articles analyzed, the authors identified a credible case a spider bite could indeed lead to an infection. This episode involved a large spider from Australia who weaves a golden web and bacteria rarely found in humans. "The bite led to a full lesion pus which persisted for more than two months. »

Nevertheless, Richard Vetter concludes: "Although the spider bite can be a causative agent of bacterial infection attractive and plausible, the data show that it is highly unlikely." So it was by mistake that doctors and patients incriminate spider bites. For example, in a study of 182 Southern California patients who complained of spider bites, less than 4% underwent poisoning caused by a spider. In contrast, 86% of them had a skin infection. The real issue is therefore quite different. Spiders are actually scapegoats ...


Consequence of these misdiagnoses: patients may develop arachnophobia unjustified and excessive use of pesticides in their homes ...

Some fatty acids protect against diabetes

Tuesday, October 14, 2014 / No Comments

Researchers have identified a new class of fatty acids produced by the human body that has a protective effect against diabetes. The discovery could lead to new treatments.

The authors of an article published in the journal Cell found that giving new lipid laboratory mice genetically altered so that they develop the equivalent of adult onset diabetes (type 2) human, they showed a reduction of their high level of blood sugar. The researchers determined that parallel those with very low levels of these fatty acids had an inverse risk of diabetes. They also discovered that such high lipid was resistant diabetes in mice.


All this suggests that such lipids could be used for therapy against diabetes, say scientists who conducted the study, a team from the Salk Institute in La Jolia California and Beth Israel Deaconess Medical Center (BIDMC) in Boston (Massachusetts).

Lipid FAHFA benefactors

"High levels of these lipids appear to be associated with beneficial effects in mice as in humans," notes Dr. Barbara Kahn, vice president of the Faculty of Medicine at BIDMC, and lead author of the study. "Based on their biology, these lipids can be added to the small list of good fats," says another contributor, Alan Saghatelian, Professor of Biology at the Salk Institute. "These fatty acids are amazing because they can also reduce inflammation, which suggests that in addition to diabetes, we may find opportunities to use these molecules to combat chronic inflammation such as Crohn's disease or arthritis," he added.

The lipids present in blood as bad cholesterol are excess associated with cardiovascular disease. In recent years, researchers have shown that certain lipids were contrary to good health, such as omega-3 that can be found in oily fish and some vegetable oils.

This new class of lipids (FAHFA) had not previously been identified in cells and tissues because their concentrations are very low, which makes them difficult to detect, the researchers said. "This research may indicate that changes in lipid levels FAHFA, hitherto unknown, play a role in the onset of diabetes" ad Saghatelian. "We hope that this discovery will enable the development of new therapies to boost the capacity of the human body to control blood sugar," he adds.

Cancer: EBC-46, derived from a rare plant is effective against solid tumors

Monday, October 13, 2014 / No Comments

A molecule extracted from the seed of an Australian plant is effective against solid tumors, it regresses in a few hours, it seems, without causing side effects. After several years of animal testing, preclinical trials on mice were positive. Clinical studies on humans have just been authorized.

Conducted by an Australian pharmaceutical company, Q-Biotics, studies have shown anti-tumor activity of a molecule called EBC-46, derived from the seeds of euphorbia, Hylandia dockrillii the blushwood berry that grows only northern Queensland, Atherton Tablelands in. These tests were first carried out on dogs, cats and horses. Tests were also conducted in Tasmanian devils, carnivorous canine appearance and whose populations were decimated by an epidemic of cancer of the face marsupials.


The molecule has shown efficacy when applied to the surface of the tumor and especially inside injection. It causes tissue necrosis and destruction of the blood vessels. According to Q-Biotics, it would be operative against a wide variety of cancers: prostate, breast, lung, or melanoma and tumors in the neck. His administration could then replace chemotherapy.

Preclinical studies have recently been performed by an independent institution, the Institute of Medical Research QIMR Berghofer. The team chose an animal model of cancer, in this case the mouse. The findings, published in the journal Plos One, seem pretty amazing. The drug works by activating protein kinase C, as does a known product, the phorbol ester PMA. It is the speed and efficiency of EBC-46 seem larger. The regression of the tumor is sustainable "in 70% of cases" reported Glen Boyle, one of the authors of the study in a statement from the institute. The effect, especially, is fast. "In most cases, a single injection will cause the death of tumor cells in four hours. "For a chemotherapy regimen is to be measured in weeks the effect. Moreover, according to Q-Biotics, there would be no side effects here.

The next step will be clinical trials in humans as they have been approved by Australian health authorities. However, the institute underlines that QIMR Berghofer EBC-46 acts only on tumors with which this molecule is in direct contact. They must therefore be visible to be treated in this manner. Melanomas or neck tumors, for example, would be a good target. Furthermore, this mode of action precludes using such treatment against metastasis. If the efficiency of the EBC-46 is proven, we must learn to synthesize, or to grow across this rare plant ...

Psilocybin contained in some hallucinogenic mushrooms could help smokers kick the habit

Saturday, September 20, 2014 / No Comments

Psilocybin contained in some hallucinogenic mushrooms could help long-term smokers to quit. This is the result of a small pilot study that got 80% success rate on a sample of 15 smokers.
In the years 1950-1970, research has focused on the use of hallucinogens to treat drug addiction (alcohol, opioids). This promising field of study had been abandoned due to the controversies surrounding the use of these products. In 2012, work has been suggested that treatment with LSD could help with alcohol withdrawal. A recent article in the Journal of Psychopharmacology shows the results of research conducted at Johns Hopkins (Baltimore) based on the use of an active ingredient in magic mushrooms, psilocybin, smoking cessation.

In their study, the researchers recruited 10 men and five healthy women. On average, those who smoked 19 cigarettes per day and smoking are spread over a period of 31 years. All participants had tried several times to quit smoking without success. The first dose of psilocybin was administered as a pill each participant the day he decided to resign; There was a moderate dose of 20 mg / kg 70 The highest dose (30 mg / 70 kg) were given at two weeks and after 8 weeks. If desired, participants may receive only moderate doses in the last two sessions. The clinical approach also included a behavioral therapy.

During each session lasts 6-7 hours, participants who could listen to music and had to rest, were followed by members of the research staff. After 6 months, 12 of 15 participants quit smoking. From a biological point of view, the exact mechanism of action is not known psilocybin. But it is assumed that the molecule helps to break the flow of thoughts and addictive behaviors that are rooted in individuals who smoked for years.

Psilocybin seems more effective than anti-smoking treatments

The success rate in this experiment was 80% after 6 months, much better than existing therapies (if not taken into account the small sample size). Therefore, varenicline (Champix) would give about 35% success, so it is considered the most effective medication for smoking cessation. According to Matthew Johnson, author of the study, other therapies - Nicotine replacement and behavioral therapy - have success rates below 30%.

Treatment with psilocybin led to side effects such as increased blood pressure, headaches and anxiety. However, according to researchers, it was possible to manage these side effects with an appropriate medical response. Moreover, medications for smoking cessation (bupropion, varenicline), taken daily, can cause nausea or insomnia.


Under the terms of the article should not be seen in these results an incentive to take psychedelic drugs to quit. However, one can imagine that psilocybin based medicine only day administered as part of a smoking cessation program also involves behavioral therapy. This study involved a small number of participants, which must still be cautious before extrapolating the results.

US Government seeks to prevent overuse of drugs and encourage development of new treatments for infection.

Thursday, September 18, 2014 / No Comments

White House takes aim at antibiotic resistance

US President Barack Obama ordered new steps on 18 September to combat the spread of antibiotic-resistant bacteria.
It is a deadly problem: According to the Centers for Disease Control and Prevention Disease, the antibiotic-resistant infections kill at least 23,000 people become ill and 2 million each year.

A national strategy issued by the White House outlined a series of measures to address the declining effectiveness of antibiotics; many are similar to those identified by the World Health Organization in April. These include monitoring systems to track the spread of antibiotic-resistant infections in health centers and agriculture, financial and regulatory incentives for researchers and pharmaceutical companies to develop new antibiotics, and to develop methods for rapid diagnosis of infections resistant to antibiotics.

A decree signed by Obama orders a new government task force to develop a plan next year to implement the strategy.

The White House also announced a contest co-sponsored by the Canadian Institutes of Health National Authority United States and biomedical research and advanced development, which will award $ 20 million to develop a rapid test to identify infections resistant to antibiotics.

John Holdren, director of the White House Office of Science and Technology Policy, said that resistance to antibiotics is not only a health issue but a national security issue. "What we see in the possibility of infections that have no remaining potential antibiotic is rampant spread of infection ... which could undermine social stability," he said. "We see the potential for a large increase in costs to the economy, which would reduce the country's ability to respond to other threats."

The White House action comes along with the publication of a long-awaited report on the antibiotic resistance of the Board of Advisors to the President for Science and Technology (PCAST​​). Analysis suggests PCAST ​​spend $ 900 million this year for pathogens of national surveillance systems - double its current level - and the development of infrastructure to accelerate clinical trials of new antibiotics. The report also recommends that funding of basic research in the spread of antibiotic resistance and alternatives for farmers who use antibiotics to promote livestock growth.

PCAST ​​also suggests that the government requires hospitals to adopt a program of antibiotics if they wish to continue receiving reimbursement from Medicare, a program that provides health insurance for people over 65, according to a recent CDC report, to 50% of antibiotic use in hospitals is unnecessary.
But some experts say the PCAST ​​report does not give enough attention to the use of antibiotics in agriculture, which contributes to the spread of resistant bacteria.

In December 2013, the Food and Drug Administration (FDA) has issued voluntary guidelines asking companies to change the labels of your medications to be marketed to fatten livestock, and require the intervention of a veterinarian to prescribe these drugs. PCAST ​​said that the guidelines were approved by the 26 leading manufacturers of antibiotics to farm animals.

The PCAST ​​report suggests that the FDA will continue to monitor such measures lead to a reduction in antibiotic use and the degree to which agricultural use contributes to resistance. But it has some details on how exactly this would work or monitoring tests lead to higher standards, said Mae Wu, an attorney with the Natural Health Resources Defense Council in Washington DC.

"It's a little too passive," he said. "How long must we wait for stronger measures to reduce the amount of use of antibiotics on farms is taken?" She said the report does not do enough to combat the widespread use of antibiotics to prevent disease rather than treat a disease known.