Hidden within the genetic codes of many people lies a fascinating remnant of
our evolutionary past: a small portion of Neanderthal DNA, persisting tens of
thousands of years after Neanderthals vanished. For most non-African
populations, about 1% to 2% of their DNA can be traced back to these ancient
ancestors.
Two recent studies published in Nature and Science have shed
new light on the evolutionary relationship between Neanderthals and modern
humans. These findings suggest that interbreeding occurred during a specific
window—between 43,500 and 50,500 years ago—as early humans migrated out of
Africa into new regions.
Over the following 100 generations, much of the Neanderthal DNA was lost due
to natural selection, but certain traits, including those linked to skin
pigmentation, immune response, and metabolism, were retained. This research
narrows the timeline for when modern humans spread across continents and
reveals that earlier human populations, such as those found in Europe over
50,000 years ago, did not contribute to present-day lineages.
The research teams took distinct approaches. One group analyzed ancient
genomes from 59 individuals who lived between 2,000 and 45,000 years ago,
alongside data from 275 modern individuals. Their findings indicate that
Neanderthal gene flow into humans occurred over roughly 7,000 years, possibly
in the Middle East.
The second team focused on six ancient genomes from remains found in a German
cave dating back around 45,000 years. These represent the oldest nuclear
genomes of modern humans identified so far.
These discoveries underscore the sophistication of modern anthropology and the
ability to reconstruct ancient events through genetic analysis, offering
deeper insights into the complex story of human history.
As Johannes Krause from the Max Planck Institute noted, "Human history is not
just a story of success. We actually went extinct several times."
Neanderthal DNA and Human Evolution: New Clues from Ancient Genomes
Researchers have uncovered more about the relationship between modern humans
and Neanderthals, shedding light on a pivotal moment in evolutionary history.
The findings were bolstered by the analysis of DNA from individuals found at
two ancient sites: Ranis, in present-day Germany, and a cave in Czechia,
located about 140 miles apart.
The remains at these sites, dating back to roughly the same period, revealed
that some individuals from Ranis were closely related — within five or six
degrees of kinship — to the one found in Czechia. This suggests the
populations at both locations were part of a small, isolated group, estimated
to number around 200 individuals. Tragically, this population left no
descendants, as their genetic lineage went extinct.
Despite this, these individuals’ genomes bore the same Neanderthal DNA markers
as other ancient remains studied, reinforcing the theory of a singular
“admixture” event, or interbreeding, between humans and Neanderthals.
Researchers now estimate this event occurred between 43,500 and 50,500 years
ago, likely as humans migrated out of Africa and encountered Neanderthals in
regions such as the Middle East.
Experts like Joshua Akey of Princeton University noted the significance of the
studies, which used independent data and methods to reach similar conclusions,
providing robust confidence in the findings. Chris Stringer of the Natural
History Museum in London added that these results refine the timeline of human
migration, confirming that the ancestors of modern populations in regions like
China and Australasia arrived after the interbreeding event.
Additionally, the research clarified that interbreeding with Denisovans,
another extinct human relative, occurred later, highlighting a complex history
of interactions among ancient species.
Yet, questions remain. The frequency of mating between humans and Neanderthals
is still uncertain, as is the full impact of Neanderthal and Denisovan DNA on
modern human traits. The mystery of why Neanderthals disappeared about 39,000
years ago also lingers.
Some researchers, including Akey, speculate that frequent interbreeding may
have led to the gradual absorption of Neanderthals into human populations,
contributing to their eventual extinction. “My inclination is to think that
mating was pretty frequent,” Akey said, though he acknowledges this theory
remains speculative.
These findings underscore the complexity of human evolution, revealing a
tangled web of interactions, migrations, and extinctions that shaped the
genetic blueprint of modern humanity.