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First U.S. Case of H5N1 Bird Flu in a Child Confirmed, Risk to Public Remains Low

Friday, November 22, 2024 / No Comments

The U.S. Centers for Disease Control and Prevention (CDC) confirmed on Friday the nation's first case of H5N1 bird flu in a child. The child experienced mild symptoms, is recovering, and received antiviral treatment for flu.

California’s public health department initially reported the case on Tuesday, emphasizing there is no evidence of human-to-human transmission. Family members of the affected child tested negative for the virus.

The CDC reiterated that there is no indication the virus spread from the child to others but is continuing to conduct contact tracing. While the initial test detected low levels of the virus, a subsequent test several days later returned negative for H5N1 but positive for other common respiratory viruses.

The CDC emphasized that no cases of person-to-person transmission of H5N1 have been documented in the United States to date, and the risk to the general public remains low.

This marks the 55th human case of H5 bird flu in the U.S. this year, with 29 of those cases occurring in California. Most infections have been linked to exposure to infected poultry or livestock, primarily among farm workers.

Given the potential for bird flu viruses to mutate and spread among humans, California health officials are closely monitoring both human and animal infections. The CDC and state health authorities have urged the public to avoid contact with sick or dead wild birds as a precautionary measure.

Cannabis May Cause Genetic Damage That Increases Cancer Risk

Tuesday, November 19, 2024 / No Comments

A groundbreaking study published in Addiction Biology warns of the serious health risks cannabis may pose, including genetic damage that could lead to cancer and affect future generations. Conducted by researchers from the University of Western Australia, the study found that cannabis can cause "genotoxicity" — damage to the genetic material in cells.
This type of cellular harm can interfere with mitochondrial function, which is crucial for energy production and chromosome integrity, ultimately leading to chromosomal damage.

Chromosomal damage is linked to cancer, accelerated aging, and even birth defects. The study highlights that these genetic risks are not limited to the individual user; they could potentially be passed down to offspring, raising concerns about the multigenerational impact of cannabis use.

Dr. Stuart Reece, one of the study's authors, emphasized that the risks of cannabis extend far beyond its immediate effects, challenging its reputation as a relatively benign substance. This research could have significant implications for public health policies, especially in regions considering cannabis legalization. It underscores the need for a deeper understanding of cannabis's long-term genetic effects, both at the individual and societal levels.

The study's findings contribute to growing evidence that the health risks of cannabis may be more complex than previously thought, advocating for more research into its genetic and cellular impacts. 

New Insights Reveal Alzheimer's Dual-Wave Progression and Hidden Early Damage

Sunday, November 17, 2024 / No Comments

Recent research has revealed that Alzheimer’s disease progresses through two distinct waves, offering new insights into its devastating impact on the brain. The first wave occurs silently, beginning years or even decades before symptoms emerge, as toxic proteins, including amyloid-beta, gradually accumulate. This early phase, often unnoticed, sets the stage for the second wave.

The second wave is marked by the rapid degeneration of neurons, driven by the interaction of accumulated proteins and other neurodegenerative processes, such as tau tangles and inflammation. This phase correlates with noticeable cognitive decline, including memory loss and impaired reasoning, hallmarks of Alzheimer’s.

Understanding these dual waves underscores the importance of early detection and intervention. Researchers are exploring ways to identify the disease during its silent stage using biomarkers and advanced imaging techniques. These insights also open doors for targeted treatments, focusing on halting or slowing down the progression during its early phase to prevent irreversible damage.

This evolving perspective on Alzheimer’s progression could significantly influence future diagnostic and therapeutic strategies. Scientists emphasize that unraveling the mechanisms driving these waves remains crucial for combating the disease effectively.

New Research Shows Standing Desks May Be Harmful to Your Health

Tuesday, November 12, 2024 / No Comments

 

Recent studies have raised concerns about the health benefits of standing desks, suggesting that prolonged standing may do more harm than good. While standing desks were initially thought to combat the risks of prolonged sitting, new findings show that standing for extended periods can lead to discomfort in the lower back, legs, and joints. 

Standing without movement can increase pressure on the spine and lower limbs, potentially contributing to long-term pain and fatigue. Experts recommend regularly alternating between sitting, standing, and moving to avoid the adverse effects of both postures. The key to health seems to lie in variety, with proper ergonomic practices playing a vital role.

 More research is being conducted to further understand how to optimize office setups for health. Adjusting height, frequency, and incorporating breaks can alleviate some of the risks associated with standing too long. Researchers urge caution, as the evidence continues to evolve, with some experts suggesting that simply standing may not provide the health benefits it was once believed to.

 Balancing sitting, standing, and walking throughout the workday may be the best approach for overall health and productivity.

Startup Lumicell Revolutionizes Breast Cancer Surgery with Real-Time Tissue Imaging

Monday, November 11, 2024 / No Comments

 

A new technology developed by the startup Lumicell, an MIT spinout, is providing surgeons with a real-time, in-depth view of breast cancer tissue during surgery, enhancing the precision and effectiveness of breast cancer procedures.

 By using a handheld scanner in combination with an optical imaging agent, the device allows surgeons to immediately visualize residual cancer cells in the surgical cavity, ensuring more complete tumor removal. This innovation helps minimize the likelihood of leaving behind cancerous tissue, which could otherwise lead to follow-up surgeries.

The technology integrates advanced imaging techniques with AI algorithms, enabling surgeons to assess tumor margins in real-time, as opposed to the current standard where pathology results take days. With this immediate feedback, surgeons can make more informed decisions during the operation, potentially reducing recurrence rates and improving patient outcomes.

 If widely adopted, Lumicell's approach could transform the standard of care by making surgeries more targeted, reducing the need for repeat procedures, and improving recovery times. The FDA's recent approval of Lumicell’s technology marks a significant step forward in personalized and precise cancer care​

Global Study Links Extreme Rainfall to Higher Mortality

Friday, November 8, 2024 / No Comments

 

A recent global study has shown a link between extreme rainfall events and increased mortality rates, emphasizing the significant health risks associated with climate change-driven weather extremes. When heavy rains occur, they can trigger flooding, landslides, and infrastructure damage, which not only directly threaten lives but also disrupt healthcare services, clean water supplies, and sanitation systems. 

This increases the risk of waterborne diseases, injuries, and even mental health challenges due to displacement and loss of property.

The study highlights that low-income and densely populated areas are particularly vulnerable, where housing and infrastructure may be less equipped to handle extreme weather. Moreover, the aftermath of such events often strains local healthcare systems, complicating the response to medical needs, and can lead to long-term public health impacts, including respiratory issues due to mold in water-damaged buildings and higher rates of infectious diseases. 

This research underscores the urgency of climate adaptation measures to prepare communities for the increasing frequency and intensity of extreme rainfall.

Study Finds Extra Education Does Not Prevent Brain Aging

Tuesday, November 5, 2024 / No Comments

 

Researchers were surprised to find that an additional 12 months of schooling did not affect brain structure or provide protective benefits.

Scientists from Radboud University Medical Centre in The Netherlands leveraged a “natural experiment” involving 30,000 British participants to precisely assess the long-term impact of an extra year of education on the brain.

Previous studies have highlighted many positive outcomes of education.

Generally, individuals who spend more time in school tend to be healthier, more intelligent, hold better jobs, and earn higher incomes compared to those with fewer years of education.

However, it remains uncertain whether extended education leads to changes in brain structure over the long term and guards against brain aging.

Many other factors impact brain structure – including childhood environment, genetic traits, and exposure to pollution – making it challenging to isolate the effects of education.

Prof. Rogier Kievit and Dr. Nicholas Judd of Radboud University recognized a “unique” opportunity to assess the effects of an additional year of schooling.

In 1972, a change in UK law increased the minimum school-leaving age from 15 to 16, while other conditions remained unchanged.

The researchers described this as an intriguing ‘natural experiment,’ an event outside their control that created exposed and unexposed groups.

For their study, published in eLife, data from 30,000 individuals who attended school during that period, including MRI scans taken 46 years later, were used, marking it as the largest brain imaging dataset globally.

The team analyzed the MRI scans for structural differences in various brain regions but found no significant differences between those with an extra year of schooling and those without.

Dr. Judd commented, “This surprised us.

“We know education has positive effects, so we anticipated that it might protect against brain aging.

“Age-related changes are evident in our MRI data, showing declines in total brain volume, surface area, cortical thickness, and poorer water diffusion. However, the extra year of education doesn’t seem to impact these areas.”

The researchers noted that while changes in the brain may have been evident right after the additional year of education, this was not captured in the study.

Kievit added: “It’s possible that education temporarily increases brain size, but it returns to its baseline later. After all, the brain must fit within the skull.

“It might be similar to physical training: intense exercise at 16 could enhance muscle size, but the effect may not last 50 years later.”

The team suggested that the extra education might induce microscopic brain changes that MRIs cannot detect.

Previous research and smaller studies have indicated that more education correlates with brain benefits.

For instance, individuals with more education tend to have better cognitive functions, superior health, and higher job prospects.

Kievit pointed out, however, that these associations are not evident in brain structure as viewed through MRI.

He concluded, “Our findings emphasize caution when interpreting causation from mere correlations.

“While we observe correlations between education and the brain, we do not see evidence of changes in brain structure.”

Wearable Devices for Neurons: Probing Brain Function and Restoration

Saturday, November 2, 2024 / No Comments


 MIT Scientists have developed innovative "wearable" devices that can wrap around neurons, offering new possibilities for probing and interacting with subcellular regions of the brain. These microscopic devices are designed to conform tightly to individual neurons, allowing for high-precision measurements and interactions at the cellular level. The concept is similar to wearable technology for humans but scaled down to interact directly with cells.

The primary applications of these neuronal "wearables" include detailed mapping of electrical and chemical signals in subcellular areas, which could provide deeper insights into how the brain functions at the most intricate levels. By accessing and monitoring these tiny regions, researchers can better understand processes like signal transmission and synaptic activity. This could lead to breakthroughs in understanding neurological diseases and disorders.

Moreover, there is potential for these devices to be used in therapeutic applications. For example, they could be engineered to deliver electrical stimulation or drugs directly to specific parts of the brain, possibly aiding in the restoration of lost brain functions or modifying neuronal activity to address disorders such as epilepsy or Parkinson's disease.


This new approach marks a significant step in neurotechnology, merging micro-engineering and neuroscience to create tools that are more integrated with biological structures than ever before.

New study shows that blood-based tests for colon cancer are not as effective as colonoscopies

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A study led by Stanford Medicine has found that blood tests can be a useful screening option for colorectal cancer for patients who might otherwise not undergo screening. However, these blood tests are not as effective as traditional screening methods like colonoscopies or stool-based tests.

Colonoscopy remains the gold standard for detecting colorectal cancer because it allows direct visualization of the colon and removal of precancerous polyps. Stool tests, such as fecal immunochemical tests (FIT) or stool DNA tests, are also proven to be effective non-invasive screening methods. Blood tests, while more convenient, tend to have lower sensitivity and may miss more cases compared to these established methods.

The researchers suggest that blood tests could play an important role in increasing screening rates among individuals who avoid more invasive or inconvenient methods. This could help identify cases of colorectal cancer earlier, when treatment is more effective. The findings highlight the need for continued patient education about the most effective screening options and the potential role of blood tests as a secondary alternative for those unwilling or unable to undergo standard screenings.

Blood Analysis Finds Heart Damage Linked to Inflammation in Long COVID

Thursday, October 31, 2024 / No Comments
Research led by the University of Queensland has identified inflammatory markers in the blood of long COVID patients, potentially explaining why many continue to suffer from cardiovascular issues


Associate Professor Kirsty Short explained that her team aimed to uncover the reasons behind persistent chest pain and heart palpitations frequently reported by long COVID patients.

"We found elevated cytokine levels—proteins that regulate inflammation—in blood samples from individuals about 18 months after SARS-CoV-2 infection," Dr. Short said.

"Lab tests demonstrated that even trace amounts of these cytokines had a direct impact on cardiomyocytes, the heart cells responsible for its pumping function."

According to Dr. Short, the role of chronic inflammation in prolonged cardiovascular symptoms was previously unclear, particularly in people with symptoms persisting beyond a year post-infection.

Published in Nature Microbiology, the study analyzed blood samples from 50 participants in Australia, including those with long COVID lasting over a year, people who had recovered from COVID, and individuals never infected with the virus.

The research team utilized "immuno-storm chip" nanotechnology, created at UQ's Australian Institute for Bioengineering and Nanotechnology (AIBN), to detect trace cytokine levels and cardiac tissue damage markers at single-molecule resolution in long COVID patients.

"It's still early days, and these findings need validation in additional patient groups, particularly those infected with newer SARS-CoV-2 variants," Dr. Short said.

"We’re also interested in exploring whether our results might apply to other long COVID symptoms, such as neurological or respiratory issues, since this study specifically focused on patients with chest pain and/or heart palpitations."

"Despite these limitations, this work sheds new light on the complexity of long COVID and could pave the way for improved diagnosis, treatment, and understanding of the condition."

This research was led by UQ Ph.D. candidates Jane Sinclair from the School of Chemistry and Molecular Biosciences (SCMB), Courtney Vedelago from AIBN, and Dr. Feargal J. Ryan from the South Australian Health and Medical Research Institute.

The study was a collaborative effort involving UQ's SCMB, School of Mathematics and Physics, AIBN, Institute for Molecular Bioscience, Faculty of Medicine, along with the South Australian Health and Medical Research Institute, Flinders University, the University of Adelaide, the Australian National University, Mater Health Queensland, Mater Research Institute—UQ, and QIMR Berghofer Medical Research Institute.

Research samples were provided by the COVID OZGenetics study, Central Adelaide Health Network, and the David Serisier Research Biobank at Mater Research.














A New Implant Shows Promise in Reversing Drug Overdoses

Wednesday, October 30, 2024 / No Comments

 

This implantable device, though not yet tested in humans, shows promise in reducing opioid deaths, particularly among high-risk individuals. Designed to be placed under the skin similarly to a pacemaker, it has the potential to automatically detect an overdose and deliver life-saving naloxone.

 Joanna Ciatti/Northwestern University


Naloxone has been a life-saving treatment for reversing opioid overdoses, but its effectiveness depends on someone being present to administer it promptly—a challenge when many overdoses occur when individuals are alone. To address this issue, researchers have developed an implantable device called the Naloximeter. Powered by a battery and inserted under the skin, the device is capable of detecting the onset of an overdose, then automatically releasing naloxone into the bloodstream while alerting first responders. This innovative approach, reported on October 23 in Science Advances, has so far been tested only in animal models.

Researchers hope the Naloximeter implant could benefit high-risk individuals, particularly those who are newly sober after treatment or incarceration. People in early recovery face a 10 to 16 times higher risk of fatal overdose, as their opioid tolerance has diminished.
In 2023, the U.S. saw over 80,000 opioid overdose deaths. Robert Gereau, a neuroscientist at Washington University in St. Louis, emphasized the urgent need for new harm reduction methods to combat the worsening fentanyl crisis.

Traditional methods, like safe injection sites and hotlines, offer support when bystanders are present, while newer apps can alert responders. The Naloximeter, however, goes further: it actively delivers naloxone during an overdose, filling a critical intervention gap.
The Naloximeter’s sensor monitors oxygen levels, detecting the sudden drops characteristic of overdose. In future human applications, an alert would appear on the person’s phone, allowing them to dismiss it if false; otherwise, naloxone would be administered.

In animal trials, Gereau’s team tested various delivery methods. In pigs, they found that an intravenous catheter within the implant worked best, delivering 0.7 milliliters of naloxone in under a minute—enough for rapid brain action, notes materials scientist Joanna Ciatti of Northwestern University.

While clinical trials in humans are still distant, the technology is promising. Addiction researcher Monty Ghosh at the University of Alberta points out that its success will depend on the device's invasiveness, cost, and whether those at risk are open to such an intervention.

Scientists Discover Six New Genes Associated with Increased Cancer Risk

Tuesday, October 29, 2024 / No Comments

Scientists at decode genetics/Amgen, along with collaborators, have identified six novel genes with rare germline variants associated with cancer risk. Published in Nature Genetics under the title "Gene-based burden tests of rare germline variants identify six cancer susceptibility genes," the study provides new insights into genetic predispositions to cancer.

Certain cancers are linked to rare genetic variants inherited from birth, significantly increasing cancer risk. Discoveries of variants like those in the BRCA1 and BRCA2 genes have led to advancements in early detection and targeted therapies, which have improved outcomes for individuals with these mutations.

In this study, researchers analyzed genetic data from 130,991 cancer patients and 733,486 controls, all of European descent, across 22 cancer types. The gene-based burden analysis revealed four novel genes linked to higher cancer risks: BIK for prostate cancer, ATG12 for colorectal cancer, TG for thyroid cancer, and CMTR2 for both lung cancer and cutaneous melanoma. Variants in these genes increased cancer risk by 90% to 295%, although the study design limits accurate lifetime risk estimates.

Remarkably, the researchers also identified genes with rare variants associated with reduced cancer risk. Specifically, loss of AURKB was found to confer protection against various cancers, while loss of PPP1R15A was linked to a 53% reduction in breast cancer risk. This suggests PPP1R15A inhibition could serve as a potential therapeutic approach for breast cancer.

These findings shed light on the biological mechanisms of cancer susceptibility, paving the way for improved screening and treatment strategies.


Off-label glucose-lowering drugs Poses Risks for Type 1 Diabetes Patients

Monday, October 28, 2024 / No Comments

 

A collaborative study led by Emory University's Rollins School of Public Health highlights the risks associated with prescribing off-label glucose-lowering medications to individuals with type 1 diabetes (T1D). Researchers express concern over the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 (SGLT2) inhibitors, which have demonstrated cardiovascular and renal benefits in type 2 diabetes but pose unique dangers for T1D patients.

SGLT2 inhibitors, in particular, are linked to a significant risk of euglycemic diabetic ketoacidosis, a potentially life-threatening condition characterized by dangerously high acid levels in the blood, common in T1D individuals. Consequently, these medications have been removed from use in T1D patients in Europe, and the U.S. Food and Drug Administration (FDA) has not approved them for this population.

GLP-1RAs are known for promoting weight loss, which can complicate insulin needs and lead to risks such as ketoacidosis and hypoglycemia in T1D patients. The research letter published in JAMA emphasizes the urgent need for further studies to assess the safety and efficacy of these medications for T1D.

Analyzing data from the Epic Cosmos database, the study identified 943,456 T1D patients from 2010 to 2023. It found that those prescribed SGLT2 inhibitors had higher rates of pre-existing cardiovascular issues and chronic kidney disease, indicating these drugs are being used off-label to manage complications associated with T1D.

Meanwhile, the usage of GLP-1RAs increased significantly among T1D patients, particularly for managing obesity, which is a vital aspect of diabetes care. The study noted that the percentage of T1D patients prescribed GLP-1RAs rose from 0.3% in 2010 to 6.6% by 2023.

Despite the growing trend in off-label prescriptions, concerns remain regarding the safety of these treatments in T1D. The researchers call for prospective studies to evaluate the efficacy and safety of GLP-1RAs and SGLT2 inhibitors for T1D patients before widespread adoption of these medications. Until more evidence is available, caution is advised in their prescription for individuals with type 1 diabetes.

CO2 concentration exceeds 400 ppm, a record

Monday, May 11, 2015 / No Comments

According to NOAA, the rate of concentration of carbon dioxide in the atmosphere, in March exceeded 400 parts per million, the highest ever measured content. Yet, emissions have stagnated in 2014.

March 2014: 398.10 ppm (parts per million by volume). March 2015: 400.83 ppm. NOAA, the National Oceanic and Atmospheric Agency US, has announced a record. Every week, this rate is measured on Mauna Loa volcano in Hawaii, NOAA and establishes the monthly global content based on 40 sites worldwide. This is the first time the content of the atmosphere of carbon dioxide (carbon dioxide, or CO2) exceeds 400 ppm.

Yet, according to the IEA (International Energy Agency), as reported by the press NOAA, global emissions of carbon dioxide by fossil fuel combustion stagnated between 2013 and 2014. The atmospheric content has nevertheless increased by 2 25 ppm per year between 2012 and 2014, "the highest increase recorded over three years."

Since the beginning of the industrial age, the concentration of CO2 has increased by 120 ppm, "half of the increase occurring since the 1980s." According to James Butler, NOAA, "the elimination of approximately 80% of emissions from fossil fuels stop the progression of the atmospheric content of carbon dioxide, but it will not decrease and no further reduction would only do so slowly ".

Diesel particles attack the liver function

Tuesday, April 21, 2015 / No Comments

Allowing the body to eliminate certain toxic elements, the liver plays a vital role in the human body. A study has shown that diesel particulate disrupt its detoxifying liver function by blocking certain carriers. The health implications are not yet well known. This could include enhancing the carcinogenic effects of diesel related to oxidative stress.

Diesel station! The fine particles are not only toxic to the lungs, but they are also able to cross the lung barrier and attack other organs. He had indeed been shown that these particles alter the function of certain liver enzymes. A new study shows this time they can also impair the liver's detoxification function, that is to say its ability to sort and eliminate toxic waste to the body.

The origin of this discovery researchers (Inserm Unit 1085, research institute Health, environment and labor, Rennes) worked in vitro on liver cells (hepatocytes) in culture. They have them exposed to extract particles from combustion of a diesel engine (DEP Diesel exhaust particles) at doses equivalent to those inhaled by an individual living in a polluted environment. The researchers then measured the level of expression and activity of several carriers at the cell surface. Their findings appear in the journal Plos One.

These hepatic transporters ensure the passage of molecules circulating in the blood to the inside of the liver. Bile then led to the elimination of these substances. The whole system allows the body to get rid of natural waste products from the cells, medicines or drugs. However, the authors found that DEP reduces the expression of genes encoding these transporters and block the activity of several of them. The phenomenon is observed when the cells are exposed to low levels of particles.

The MRP2 and OATP transporters inhibited

In particular, researchers found a strong inhibition of MRP2 and OATP transporters involved in the hepatic elimination of many toxic drugs, but also in that of sex steroid hormones and thyroid hormones. Blocking the activity of MRP type carriers could also disrupt control circuits of glutathione, an important endogenous antioxidant molecule.

At this point, even if it comes to work in vitro, the spectrum of clinical consequences envisaged by the authors is wide: endocrine disruption, disturbance elimination of drugs and endogenous metabolites or excessive oxidative stress to poor elimination of free radicals, which can contribute to the development of chronic diseases. "This would include the effect of strengthening the carcinogenic effects of diesel favored by oxidative stress," says Olivier Fardel, co-author of this work to the research institute on health, the environment and labor.


Assumptions that drive to continue this work: for example, the authors wish to look towards the carriers present in the pulmonary cells (some of which are similar to those found on hepatocytes), focusing in particular on carriers associated with carcinogenesis. They count as precisely identify chemical molecules involved in the inhibition of transporters in the cocktail particles used in the context of their work. Finally, they want to extend their studies to potential interactions of membrane transporters with other chemical pollutants.

Eating too much fat may increase the risk of psychiatric disorders

Sunday, April 5, 2015 / No Comments

Diets high in fat may increase the risk of psychiatric disorders. Indeed, they change the composition of the intestinal flora, which also plays a role in brain health.

The intestinal flora (or gut microbiota) has about 100,000 billion bacteria, representing about 1,000 species. These microorganisms are involved in different biological functions: digestion, growth, inflammation, immunity, protection against pathogens. However, changes in the intestinal flora appear to be involved in certain diseases, including neuropsychiatric problems. For example, probiotics taken orally, expected to act on the composition of the intestinal flora, can reduce anxiety.

In addition, the prevalence of mental illness, such as depression and dementia increases with obesity. Studies have shown deficits in learning, memory, executive function in obese people compared to non-obese patients. Modern diets rich in fats and sugars, promote alterations in the gut microbiome.

Louisiana State University researchers have therefore asked whether the microbiome associated with obesity alter the behavior and cognition, even in the absence of obesity in the individual. For this, they used mice non-obese adults who followed a normal diet, but who they are transplanted mouse intestinal microbiota that were fed a high fat diet or a control diet. Their findings appear in Biological Psychiatry.

Anxiety, memory problems, repetitive behaviors

The animals that received microbiota of mice fed the fat have been changes in their behavior: increased anxiety, memory problems and repetitive behaviors. There was also a negative impact on their health: an increase in intestinal permeability and inflammation markers and brain inflammation signs that may have contributed to changes in behavior.

This article suggests that diets high in fats affect the health of the brain changes induced by food in the intestinal flora enough to impair brain function in the absence of obesity. The composition of the intestinal microbiota therefore influences the behavior of the individual.


Microbial metabolism of the gut produces histamine and other neuroactive mediators that could stimulate local nervous system. The gut-brain axis is therefore a potential target for new therapeutic interventions imagine against psychiatric diseases.


Men Never Remember and Women Never Forget

Sunday, March 22, 2015 / No Comments

The gradual deterioration of memory is a normal process associated with aging. But men seem affected earlier than women. Possible cause: that would be protective estrogen in women.

Progressive memory loss is a natural phenomenon during aging, which does not necessarily mean that the individual risk of developing dementia such as Alzheimer's. The anatomical level, this disease is characterized by accumulation of amyloid plaques in the brain. Some people carry the APOE ε4, have a higher risk of developing it.

Researchers at the Mayo Clinic studied the effect of age, gender, APOE ε4 gene and on memory, brain structure and amyloid β in adults. For this, they examined the brain structure of 1,246 people aged 30 to 95 years who had normal cognitive function. 1209 were between 50 to 95 years and 37 between 30 and 49 years to be exact. The researchers were interested in the volume of the hippocampus, a brain area important for the formation and storage of memory. Their findings appear in JAMA Neurology.

The hippocampal volume was reduced slowly and steadily from age 30 to the mid-sixties, but soon beyond. Overall, men had poorer memory than women, especially after 40 years, and the volume of the hippocampus was smaller in men than women, especially after 60 years. One hypothesis to explain this more rapid decline in men is hormone: estrogen might help women prevent damage to brain neurons to the middle of their lives.


Amyloid accumulations increase after 70 years

The researchers also used Pet scans to study amyloid accumulation in the brains of participants. They observed that there were no differences between men and women. Overall, amyloid levels were low in most people before the age of 70, but then increased.

Overall, the volume of the hippocampus and the memory did not differ, that individuals carry or not the predisposing allele in Alzheimer's disease. But after 70 years, those who carried the APOE ε4 allele had significantly more amyloid than others. The age at which 10% of the population was positive amyloid was 57 years for those who carried this allele and 64 for others.

Eventually, the worsening of memory and hippocampal volume occurs earlier than the accumulation of amyloid. This suggests that, in middle age, amyloid deposits are not responsible for the loss of memory or volume of the hippocampus. Alzheimer's disease and amyloid deposits are set up later, in a context of pre-existing cognitive and structural decline associated with aging

A cuff-thermometer solar

Saturday, February 28, 2015 / No Comments

A team of Tokyo University researchers recently presented a flexible cuff-thermometer. Self-powered by a solar panel, it sounds an alarm when the patient's temperature becomes too high. Made from organic components through an inkjet printer, cheap and disposable product is intended for use in a hospital setting.

The development of sensors to monitor vital functions is growing, whether smart textiles for sports or medical devices. Examples are numerous developments around the epidermal stamps. The stakes of these innovations are to design devices that are both minimally invasive, energy efficient and inexpensive to produce.

It is in this context that a team of Tokyo University researchers has developed a flexible cuff thermometer powered by a solar panel. Used on the skin or clothes, it beeps when the body temperature of the user exceeds the preset threshold can be between 36.5 and 38.5 ° C.

The cuff combines a flexible solar panel consisting of solar cells, amorphous silicon (a-Si), a piezoelectric speaker, a temperature sensor and a power supply circuit. The latter has been made from organic components deposited by an ink jet printer on a polymer film.

All elements of the cuff thermometer are flexible (flexible components), either photovoltaic cells (solar cells), the piezoelectric speaker (piezoelectric speaker), the fuel system and its management based on organic compounds (organic circuits) or the temperature sensor placed under the arm. © University of Tokyo

An inexpensive, disposable product for hospitals

The researchers say this is the first time such a device works with an organic origin supply circuit. This allows to increase by more than seven efficiency of the solar panel in indoor lighting conditions. This type of circuit is also configured to emit a sound: again, this would be a first. Flexible, self-powered, this armband could be manufactured at a low cost. What consider a single use, which perfectly appropriate for use respecting the rules of hygiene in hospitals.


Moreover, designers cuff specify that this system could be combined with the detection of other vital functions such as heart rate, blood pressure or sweating. The concept has been presented at the International Solid State Circuits Conference (IEEE) held this week in San Francisco (United States). There are currently no commercial project for this innovation.

A dangerous virus probably transmitted by ticks

Friday, February 27, 2015 / No Comments

Bourbon virus, new to the family Thogotovirus would be responsible for the death of a man in Kansas, United States. The patient fell ill in the spring of 2014 after being bitten by ticks. He died 11 days after the onset of disease.

Ticks are arachnids mites that can transmit diseases such as Lyme disease, caused by bacteria. But they can also transmit viruses, such as the Heartland virus, recently discovered, and which, since 2012, caused the illness of eight people in Missouri and Tennessee, United States. Other viruses that may be carried by ticks: the Thogotovirus, which comprise at least six viruses (Araguari, Aransas Bay Dhori Jos, Thogoto and Upolu). Among them, the Thogoto Dhori and viruses are known to cause infections and human diseases. Antibodies against the virus Thogoto have indeed been identified in parts of Europe, Asia and Africa.

In an article published in Emerging Infectious Diseases, CDC researchers describe the case of a man in his fifties died in 2014 in mysterious circumstances. This man, who was in good health, was bitten by several ticks while working outdoors on his property in the spring of 2014. engorged tick was found on his shoulder a few days before he fell ill. He began to have nausea, diarrhea, and became increasingly ill with the following symptoms: fever, anorexia, chills and headaches. The third day, he consulted his doctor and was prescribed doxycycline, a standard treatment against diseases related to ticks.

The next day, the patient's wife found him weakened, awake but with a decreased level of consciousness, hence its transfer to the local hospital. Despite treatment, the patient had more fever. The 9th day, it was still clear but the temperature exceeded 39 ° C and difficulty breathing required an oxygen supply. Its oxygen requirements increase, he was admitted in intensive care. His renal function deteriorated and he was intubated. He died 11 days after the onset of illness of cardiopulmonary arrest.

Bourbon virus, unknown Thogotovirus

The patient was tested for a large number of viruses but as none was found, his blood was sent to the CDC (Centers for Disease Control and Prevention) for further analysis. Genetic tests then showed that the man was infected with an unknown virus until then, scientists have dubbed "Bourbon virus", county name where the patient lived. This virus belongs to the family of Thogotovirus. Although the role of the virus in the death is unclear, the authors emphasize the patient's level of high viremia in samples taken two days before his death.

The Thogotovirus can cause meningitis or encephalitis, but they were not known to have an impact on blood cells. Or test the patient showed a decline in white blood cells and platelets. These symptoms resemble those of ehrlichiosis, a bacterial disease also transmitted by ticks.

Similarly, the Heartland virus can also cause a decrease of blood cells. It is possible that the Bourbon virus was present for years without it being noticed because it would have made sick person before. One hypothesis is that usually causes mild illness too that people go to their doctor. The death of this man would be a rare case where a common virus became deadly. But it is also possible that the virus has evolved and Bourbon became more dangerous.


To protect against ticks, the CDC recommends using repellent, wear long pants, long-sleeved t-shirts and avoid wooded areas.

Are E-Cigarettes Safe?

Wednesday, February 25, 2015 / No Comments

A scientific study  has shown that inhalation of high vapor electronic cigarette dose increases susceptibility to respiratory infections and releases free radicals. Not enough to get back to smoke tobacco that stopped but total safety remains unproven.

At Johns Hopkins University (Baltimore, USA), Professor Thomas Sussan and her team wanted to know if mice exposed to electronic cigarette fumes were or were not more susceptible to respiratory infections. To find out, they arranged a first group of rodents in an inhalation chamber. The animals breathed e-cigarette vapor for two weeks at levels, it seems equivalent to those of human exposure. In the second group, mice breathing fresh air.

To measure the susceptibility to infection, scientists have divided each group into three sub-groups: in the first, the mice received - Nasal - drops containing bacteria (Streptococcus pneumoniae) causing pneumonia and sinusitis. In the second, they were exposed to a type of influenza A. In the third, they received neither bacteria nor viruses.

The results are available in the journal Plos One. In the end, the researchers found that mice that had breathed electronic cigarette fumes were much more susceptible to infections. "The fumes inhibit the ability of mice to fight viral or bacterial infections that come to nest in their lungs," says Thomas Sussan. The authors show that these vapors emit free radicals, ie toxic substances that affect DNA. Their presence has surprised scientists because they are similar to those found in conventional cigarette fumes. "These free radicals, however, are 100 times lower in e-cigarettes, says Thomas Sussan. But they are still numerous enough to damage cells. »